Comparison of two suture techniques on the inflammatory signs after third molars extraction-A randomized clinical trial.

PURPOSE: Wound closure technique is an operative factor that influences early post-operative complications after third molar surgery. This study investigates and compared the effectiveness of two closure techniques, primary closure and healing by second intention of the oblique incision on postsurgical discomfort after mandibular third molar surgery. MATERIALS AND METHODS: This is a prospective, randomized, double-blind, split mouth controlled trial. Surgical sites were divided into two groups Control group received simple sutures in both alveolar crest incision and oblique incision and intervention group received simple sutures in alveolar crest incision, while the oblique incision healed by second intention. All the patients were instructed to measure pain according to visual analogue scale (VAS) in postoperative period, swelling, mouth opening was assessed at 72h and 7 days after surgery. The wound healing was assessed on day 7. RESULTS: Thirty-five patients, who had bilateral impacted third molars of similar surgical difficulty, were recruited. Thirty-one successfully completed the study. Patients in the second intention group had significantly less pain at 24h (p < 0.27). and 48h (< 0.001), had significantly less swelling (< 0.001) and trismus (< 0.001) and patients submitted to primary closure had a better evaluation of the Landry index (p < 0.001). CONCLUSION: Healing by second intention of the oblique relaxing incision by partial surgical wound closure, in our study, were superior to the primary closure in reduction of post-operative pain, swelling and trismus. TRIAL REGISTRATION: This trial is registered at Brazilian Registry of Clinical Trials-ReBEC -UTN: RBR-5fxbqsf (https://ensaiosclinicos.gov.br/rg/RBR-5fxbqsf).

A Systematic Review of the Granular Cell Odontogenic Fibroma and Report of a New Case.

BACKGROUND: Granular Cell Odontogenic Fibroma (GCOF) is a rare odontogenic neoplasm reported over time with different names. The purpose of this study is to review all available data on the GCOF in the scientific literature, with a summary of all reported cases and a report of a new case. METHODS: This review was conducted following the PRISMA guidelines. An electronic search was performed up to November 2022. RESULTS: Thirty-nine studies reporting fifty-three cases were included. GCOF is a rare neoplasm among the odontogenic tumors, with a higher prevalence in women of the middle-aged and white population. This lesion occurs mostly on the posterior region of the mandible. Furthermore, based on clinical, radiographic, and histopathologic features, conservative treatment was the most reported choice with recurrence reported in two cases. CONCLUSION: GCOF remains controversial due to the still unsolved histogenesis.

Possible adverse effects of low-level laser on oral and oropharyngeal cancer cells: A scope review.

BACKGROUND: The effects of laser therapy on normal cells are well known and accepted, but the impact of this therapy on malignant cells are not yet fully understood. This review aims to map and outline what the scientific literature addresses on the effects of laser therapy on malignant cells. METHODS: This review article followed the guidelines of the PRISMA-ScR protocol, being all the search, analysis, and selection of articles based on it. RESULTS: After all application of the predetermined criteria, five studies were included, dated between the years 2013 and 2021. With the complete reading of the selected studies, 100% of the articles were classified as category III of the Agency for Healthcare as Research and Quality classification. Similar themes among the papers included were investigated and compared. In these five studies, the visible red and near infrared wavelengths were used, and energy densities varied between 1 and 5 J/cm2 . It was observed that low-level laser could alter the expression of cell proliferation and migration proteins, such as cyclin D1, E-cadherin, and ß-catenin. In addition, changes related to increased cell viability and metabolism were also identified. CONCLUSION: The low-level laser seems to positively regulate the proliferative, migratory, and viability capacity of neoplastic cells, depending on the protocol used. All these studies included in the review are equivalent to in vitro studies; the cells are not in such a complex environment as is an organized tissue, making it necessary to carry out more complex tests, such as in vivo research.

Access to information on oral hygiene and mothers' practices of children with microcephaly caused by Zika virus.

OBJECTIVE: To verify whether access to information about oral hygiene influenced the practices of caregivers of children with microcephaly caused by Zika virus (ZIKV). METHODS: A case series study was developed at the Mens Sana Rehabilitation Center, in the municipality of Arcoverde, Pernambuco, Brazil. The study universe included the mothers of 32 children with microcephaly caused by Zika virus. Data collection took place in June 2018 and was carried out through a structured questionnaire. The variables studied comprised socioeconomic issues, habits, diet, and knowledge about oral hygiene. Fisher's Exact and Pearson's Chi-square tests were used with a significance level of 5%. RESULTS: Out of 32 individuals eligible to participate in the study, only 27 were selected. Most mothers reported receiving information about oral hygiene from their infants (63.0%). Fisher's Exact and Pearson's Chi-square tests showed that access to oral hygiene information was associated with mother's education, family income, regular visits to the dentist, frequency of tooth brushing, age at which the infant started brushing, and brushing time (p < 0.05). CONCLUSION: Access to information about oral hygiene positively influenced the oral health care of mothers with their children with microcephaly caused by ZIKV.

The Importance of Cone-Beam Computed Tomography in Endodontic Treatment of a Mandibular Premolar With Atypical Anatomy: A Case Report.

The objective of this case study is to report the endodontic treatment of a mandibular premolar with a C-shaped root canal configuration based on the use of cone-beam computed tomography (CBCT) as a diagnostic aid and in treatment planning. A 14-year-old patient was referred for endodontic treatment of tooth No. 21. Upon examination of the CBCT, C-shaped canal anatomy was verified. The chemical-mechanical preparation was carried out with a rotary file system (rotary files 25.08, 30.05, and 35.05) and the use of 2.5% sodium hypochlorite as an auxiliary chemical substance. Clinical and radiographic follow-up was performed 6 months and 1 year after endodontic treatment. A periapical radiolucency revealed a progressive reduction, suggesting the evolution of tissue repair. This case study confirms that to achieve a favorable prognosis of endodontic treatment, in-depth knowledge of the internal anatomy of the root canal system, along with its variations, is necessary. In this regard, CBCT is an important tool to assist in obtaining the correct diagnosis and understanding the anatomical complexity to be treated. Variations of C-shaped canals are challenging due to difficulties encountered during the stages of chemical-mechanical preparation and filling. Thus, means of enhancing disinfection are needed.

Racial disparity and prognosis in patients with mouth and oropharynx cancer in Brazil

Background: Oral and oropharyngeal cancer (OPC) is an important cause of morbidity and mortality worldwide.Populations in situations of social vulnerability tend to have higher incidences of cancer, a higher proportion oflate diagnosis, greater difficulties in accessing health services, and, consequently, worse prognosis. The aim ofthis study was to evaluate the relationship between race/skin color and OPC prognosis in Brazil.Material and Methods: This is a cross-sectional epidemiological study using OPC data from the National CancerInstitute between the years 2000 and 2019. The selected variables were: gender, race/skin color, age, education,smoking and alcohol consumption, stage of the disease and disease status at the end of the 1st treatment.Results: 154,214 cases were recorded. Black men, in the 6th decade of life, were the most affected population.Blacks had a lower level of education when compared to non-blacks (p<0.001). Blacks were more exposed tosmoking and alcohol consumption (p<0.001). At the time of diagnosis, the black population was at the most advanced stage when compared to non-blacks (p<0.001). At the end of the 1st treatment, more black patients haddisease in progression, as well as more black patients died (p<0.001). Conclusions: Blacks had a worse prognosisfor OPC in Brazil. Despite the limitations, these results are important to elucidate the scenario of health disparitiesin relation to the race/skin color of the Brazilian population. (AU)

Diagnostic accuracy of immunohistochemistry compared with molecular tests for detection of BRAF V600E mutation in ameloblastomas: Systematic review and meta-analysis.

OBJECTIVE: The objective of this systematic review with meta-analysis was to critically evaluate the available data on sensitivity and specificity of IHC compared with molecular tests in the detection of BRAF V600E mutation in ameloblastomas. MATERIALS AND METHODS: This systematic review was performed based on the PRISMA statement and registered in Prospero (CRD42021259117). PubMed, Web of Science, Scopus, and Cochrane Library databases were searched for observational studies to answer the question "What is the diagnostic accuracy of immunohistochemistry compared with molecular tests for the diagnosis of BRAF V600E mutation in ameloblastomas?". Methodological quality and risk of bias assessment of the selected studies were based on the QUADAS-2. Meta-analysis based on hierarchical SROC curve model and summary measures for sensitivity and specificity were computed. RESULTS: A total of 226 records were found, but only 05 articles met the inclusion criteria, with 277 FFPE specimens of ameloblastoma included in the quantitative analysis. The sensitivity of the IHC compared to molecular tests ranged from 0.71 to 1.00, while all of the included studies showed perfect specificity (1.00). Pooled measures for sensitivity and specificity were 0.95 [95% CI 0.89, 1.00] and 1.00 [95% CI 0.95, 1.00], respectively. The diagnostic odds ratio was 4.05, and the AUC for SROC curve was calculated as 0.979. CONCLUSIONS: BRAF V600E-specific IHC using VE1 antibody showed extremely high sensitivity and specificity when compared with molecular tests in the detection of the mutation in ameloblastomas.

High prevalence of oral potentially malignant disorders and risk factors in a semi-urban brazilian city: a population-based cross-sectional study / Alta prevalencia de trastornos orales potencialmente malignos y factores de riesgo en un ciudad brasileña semiurbana: un estudio transversal de base poblacional

Background: Oral Potentially Malignant Disorders (OPMDs) are defined as lesions with a greater likelihood ofprogressing to cancer. Population-based studies that evaluate the prevalence of OPMDs are scarce in Brazil. Theaim of the present study was to determine the prevalence of OPMDs and associated risk factors in a semi-urbanBrazilian population.Material and Methods: This is a cross-sectional study, whose universe included individuals aged 40 years or olderresiding in a medium-sized city of northeastern Brazil. Data collection was divided into two steps: interview andoral examination. The outcome variable was the presence of OPMDs. The predictor variables were sociodemo-graphic characteristics and risk habits. The bivariate analysis was performed through chi-square test. The crudeprevalence ratios (PR) and its respective 95% confidence intervals (CI) were calculated. Poisson regression analy-sis with robust variance was used to calculate adjusted PRs and 95% CI.Results: Three hundred fourteen individuals were included in the study. When asked about risk habits, 58.9%reported being current smokers or ex-smokers and 62.2% reported being current drinkers or ex-drinkers. Theprevalence of OPMDs was 7.6% and was significantly higher among individuals with black skin color (p < 0.001),alcohol users (p = 0.017), and individuals with both tobacco and alcohol habits (p = 0.012).Conclusions: Therefore, the population in the present study had a high frequency of risk habits associated withPMDs of the oral cavity.(AU)

Morphological analysis and immunohistochemical expression in restorations with self-adhesive resin: A randomized split-mouth design-controlled study.

BACKGROUND: To evaluate the morphology and immunohistochemical expression of MMP-9, TIMP-3, COL-I, TNF-alfa and COX-2 in the dentinopulp complex of restorations with self adhesive composite (Vertise Flow/Kerr) compared with conventional resin composite with self-etching adhesive (Filtek Z250/3M ESPE and Clearfil SE Bond/Kuraray-Noritake). MATERIAL AND METHODS: A randomized, controlled, double-blind, split-mouth, two-arm clinical trial was conducted. Twenty-seven volunteers with third molars indicated for extraction received two deep class I restorations, one with each material. The morphology and immunohistochemical expression were measured at 15 days after the restorative procesures. The data were submitted to the Fisher`s Exct test (α=0.05). RESULTS: Through morphological analysis, a slight disorganization of the odontoblastic layer was visualized, along with a slight inflammatory infiltrate in the VERT and CSEB groups (p< 0.05). In immunohistochemical analysis, TNF-alpha, MMP-9, TIMP-3 and COX-2 demonstrated more cases of positive pulp labeling. CONCLUSIONS: Self-adhesive resin composite and conventional resin composite with a self-etching bonding agent promoted slight alterations in the dentin-pulp complex, indicating a repair ability and reversibility of the inflammatory process against aggressions of the adhesive restorative procedure. Key words:Immunohistochemistry, inflammation, randomized clinical trial, self-adhering composite, dentistry.

Doença cardiovascular e periodontite: análise de série de casos avaliando níveis de Proteína C-Reativa / Cardiovascular disease and periodontitis: case series analysis evaluating C-Reative Protein levels

As periodontopatias podem ser dos principais fatores para o agravamento de doenças, como alterações cardiovasculares. Microrganismos e produtos bacterianos encontrados nessas condições provocam intensa produção de mediadores inflamatórios, incluindo a proteína C-reativa (PCR), marcador para cardiopatias. Avaliou-se a relação dos níveis plasmáticos de PCR em pacientes com doenças cardiovasculares (DCV) e periodontite. Uma série de quatro casos acompanhados/ concluídos na referida clínica (idade entre 24 e 61 anos, todos homens). Constatada a condição de periodontite, o periograma do sextante comprometido foi realizado, junto à requisição de exames para dosagem dos níveis plasmáticos de PCR, antes e após sessão de raspagem e alisamento radicular. Em 21 a 30 dias, um periograma reavaliativo foi realizado para análise comparativa das pro fundidades de sondagem e níveis de PCR antes e após a sessão de instrumentação. Houve redução de 13,7% (paciente "A") e até 2 mm na perda de inserção (pacientes "A" e "C") dos sítios avaliados; não houve nenhuma mudança significativa nas novas dosagens dos níveis de PCR. Conclui-se que não foi possível demonstrar uma correlação entre os níveis de PCR em pacientes que apresentam concomitantemente DCV e periodontite, nesta série de casos... (AU)

Periodontal diseases are one of the main factors for aggravation of diseases, such as cardiovascular alterations. Microorganisms and bacterial products found under these conditions provoke intense production of inflammatory mediators, including C-reactive protein (CRP), a marker for cardiovascular disease. It was evaluated the relationship of plasma levels of CRP in patients with Cardiovascular Diseases (CVD) and periodontitis in the dental clinic of the UPE campus Arcoverde. A series of four cases followed at the clinic (24 to 61 years old, all men). Condition of periodontitis confirmed, the periogram of the compromised sextant was performed, together with the requisition of tests for the determination of plasma levels of CRP, before and after scaling and root planing sessions. Around 21-30 days a re-evaluating periogram was performed for comparative analysis of depths of probing and CRP levels before and after the instrumentation. There was a reduction of 13.7% (patient "A") and up to 2 mm in the loss of insertion (patients "A" and "C") of the evaluated sites; there wasn't significant change in the new doses of CRP levels. It's concluded was not possible to demonstrate a correlation between CRP levels in patients with concomitant CVD and periodontitis in this case series... (AU)

Chondrosarcoma of the Temporomandibular Joint: Systematic Review and Survival Analysis of Cases Reported to Date.

The purpose of this systematic review was to summarize the available data on TMJ chondrosarcomas and to perform a survival analysis of cases reported to date. This review was conducted in accordance with the PRISMA. Two authors performed an electronic search of case reports of TMJ chondrosarcoma published until August 02, 2020. Forty-seven studies reporting 53 cases were included. Chondrosarcomas of the TMJ were more prevalent in women, with a male:female ratio of 1:1.4. Survival curves were significantly associated with histological diagnosis (p = 0.004), reconstructive surgery (p = 0.024), recurrence (p < 0.001), and distant metastasis (p = 0.001). Only distant metastasis was independently associated with survival (p = 0.017). TMJ chondrosarcomas presented with low recurrence and higher survival rates than other chondrosarcomas. Synovial subtype, absence of reconstructive surgery, and presence of local recurrence or distant metastasis were associated with poorer prognosis.

Avaliação do conhecimento de cirurgiões-dentistas da atenção básica sobre estomatologia / Knowledge evaluation of primary health care dentists concerning oral medicine

Objetivo: Avaliar o nível de conhecimento em Estomatologia dos cirurgiões-dentistas (CD) que atuam na Atenção Básica de um município de Pernambuco, Brasil. Métodos: Este é um estudo observacional, indutivo, estatístico e de abordagem quantitativa. A população do estudo envolve os CD atuantes nas Unidades Básicas de Saúde do município. Os dados foram coletados através de um questionário elaborado pelos pesquisadores, contendo 27 perguntas sobre as lesões orais mais comuns, diagnóstico clínico e condutas frente a diagnósticos clínicos específicos. O nível de conhecimento foi mensurado a partir da média de acertos dos profissionais. Os dados coletados foram processados por meio do uso do programa estatístico IBM SPSS 20.0®. Resultados: A amostra obtida foi de treze CD. A média dos acertos nos conhecimentos específicos em Estomatologia foi de 17 (± 3,109). Quanto à classificação do desempenho geral, a maioria dos profissionais (69,2%) teve um desempenho regular. Quanto aos conhecimentos específicos sobre diagnóstico clínico, estes foram classificados como alto para a maioria (53,8%). Em relação aos conhecimentos específicos sobre as condutas adequadas frente às lesões, a classificação do desempenho foi baixa para a maioria dos participantes (84,6%). Conclusão: De modo geral, os CD obtiveram um desempenho regular de conhecimento em Estomatologia. Recomenda-se o desenvolvimento de mais pesquisas devido à escassez de discussões sobre o tema na literatura.

Aim: To evaluate the level of knowledge on oral medicine of dentists who work in Primary Health Care in the city in the state of Pernambuco, Brazil. Methods: This is an observational, inductive, statistical study with a quantitative approach. The study population involves dentists working in the Basic Health Units of the city. The data were collected through a questionnaire prepared by the researchers, containing 27 questions about the most common oral lesions, clinical diagnoses, and conduct towards specific clinical diagnoses. The level of knowledge was measured from the mean of correct answers by the professionals. Collected data were processed using the IBM SPSS 20.0® statistical program. Results: This study's sample counted on the participation of thirteen dentists. The mean of correct answers regarding specific knowledge on Oral Medicine was 17 (± 3.109). As for the classification of general performance, most professionals (69.2%) performed regularly. As for specific knowledge about clinical diagnosis, the knowledge was classified as high for the majority (53.8%). About the appropriate behaviors in relation to injuries, the performance classification was low for most participants (84.6%). Conclusion: In general, dentists obtained a regular knowledge on Oral Medicine. Further research is recommended due to the scarcity of discussions on the topic in the literature.

Conhecimento e uso da biossegurança por profissionais de saúde bucal do SUS do Sertão Pernambucano / Knowledge and use of biosafety by professionals of oral health of the SUS of Sertão Pernambucano

Objetivo: Avaliar o conhecimento e o uso dos procedimentos que envolvem a biossegurança por cirurgiões dentistas e assistentes de saúde bucal em um município do sertão de pernambucano, buscando averiguar a compreensão da necessidade e da importância da utilização da biossegurança. Métodos: Estudo observacional descritivo realizado através de questionário aplicado para os profissionais da área odontológica vinculados ao Sistema Único de Saúde (SUS) do município de Arcoverde, Pernambuco, Brasil. A amostra foi constituída de 29 profissionais da área odontológica que responderam ao questionário, sendo 9 dentistas e 20 auxiliares. Resultados: Cem por cento dos profissionais afirmam lavar as mãos antes e depois dos procedimentos. Apenas 20% dos ASB lavam o instrumental em pia fora do consultório; 90% costumam fazer a assepsia da cadeira odontológica após cada atendimento; 95% costumam fazer a assepsia da cuspideira e do equipo/cárter após cada atendimento. Conclusão: Os profissionais possuem conhecimento satisfatório acerca da biossegurança no consultório odontológico. Contudo, deve-se uma atenção especial ao uso de luvas estéreis e de campo cirúrgico durante os procedimentos necessários, bem como à disponibilização de equipamentos de proteção individual aos pacientes, a fim de minimizar o risco de contaminação cruzada.

Aim: To assess the knowledge and use of procedures that involve biosafety by dental surgeons and oral health assistants in a municipality in the backlands of the state of Pernambuco, Brazil, seeking to ascertain the understanding of the need and importance of using biosafety. Methods: This work was a descriptive observational study conducted through a questionnaire applied to dental professionals linked to the Unified Health System (SUS) in the municipality of Arcoverde, Pernambuco, Brazil. The sample consisted of 29 dental professionals who answered the questionnaire, including 9 dentists and 20 assistants. Results: One hundred percent of the professionals say they wash their hands before and after the procedures. Only 20% of ASBs wash the instruments in a sink outside the office; 90% usually perform asepsis of the dental chair after each visit; 95% usually clean the spit and the equipment / sump after each visit. Conclusion: The professionals have satisfactory knowledge about biosafety in the dental office. However, special attention should be paid to the use of sterile gloves and the surgical field during the necessary procedures, as well as the provision of personal protective equipment for patients to minimize the risk of cross contamination.

Perfil dos Pacientes Atendidos no Curso de Odontologia do Sertão de Pernambuco: Perfil dos Pacientes Atendidos no Sertão / Profile of Patients Attended at a Dental School in the Sertão of Pernambuco: Profile of Patients Attended in the Sertão

Introdução: Descrever o levantamento epidemiológico que traça o perfil dos pacientes adultos atendidos na clínica do curso de Odontologia, campus Arcoverde, da Universidade de Pernambuco. Metodologia: Estudo transversal em que foi realizada uma análise retrospectiva de 275 prontuários correspondentes aos anos de 2015 a 2017. Foram descritos: dados demográficos; queixa principal; hábito (tabagismo); presença de variação da normalidade e lesões em cavidade oral; necessidade de tratamento por especialidade e número de tratamentos concluídos. Os dados foram tabulados, e a análise estatística foi realizada no programa Statistical Package for the Social Sciences. Resultados: O gênero feminino foi o que mais procurou atendimento (64,7%), e a 3ª década de vida foi a mais atendida. As especialidades com maior necessidade pelos pacientes foram a Dentística e a Periodontia, e o hábito de fumar de alguns pacientes esteve relacionado com uma maior necessidade de tratamento periodontal. Além disso, os homens apresentaram maior necessidade desse tipo de tratamento que as mulheres. A variação da normalidade mais prevalente foi a linha alba (25,5%). As lesões mais comuns diagnosticadas clinicamente foram a leucoplasia (15%) e a queilite actínica (15%), e os homens apresentaram maior frequência da presença de lesões que as mulheres, assim como as pessoas que eram tabagistas e que trabalhavam expostas ao sol. Conclusões: A definição do perfil epidemiológico dos pacientes atendidos poderá auxiliar no planejamento de ações e qualificação da assistência... (AU)

Introduction: To describe the epidemiological profile of adult patients attended at the dental school of the Arcoverde campus, University of Pernambuco. Methodology: In this cross-sectional study, 275 medical records from the period from 2015 to 2017 were analyzed retrospectively. They included the following information: demographic data, main complaint, habit (smoking), presence of alterations and lesions in the oral cavity, need for specialty treatment, and number of treatments completed. The data were tabulated and the Statistical Package for the Social Sciences was used for statistical analysis. Results: Women most frequently sought care (64.7%) and the third decade of life was the most attended. The specialties most needed by the patients were Dentistry and Periodontics, and the smoking habits of some patients were related to a greater need for periodontal treatment. In addition, men presented a greater need for this type of treatment than women. The most prevalent alteration was linea alba buccalis (25.5%). The most common clinically diagnosed lesions were leukoplakia (15%) and actinic cheilitis (15%), and men were more frequent in presenting with lesions than women, as were people who smoked and worked in the sun. Conclusions: Defining the epidemiological profile of past patients may help in the planning of health actions and improvement of assistance... (AU)

Surgical versus non-surgical treatment of actinic cheilitis: A systematic review and meta-analysis.

OBJECTIVE: The aim of this systematic review was to compare outcomes between surgical and non-surgical treatment of actinic cheilitis (AC). MATERIALS AND METHODS: A systematic review and meta-analysis based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses guideline were performed. A search of PubMed/MEDLINE, Web of Science, and Cochrane Library databases was conducted. Articles were selected based on the inclusion criteria: randomized clinical trials, prospective/retrospective studies, and case series with at least 10 patients, with a minimum follow-up period of 6 months. A weighted remission rate (RER) and recurrence rate (RR) with a 95% confidence interval was performed. Data analysis was performed using a comprehensive meta-analysis software. RESULTS: A total of 283 ACs in 10 studies were included. About 2.5% surgically treated cases underwent malignant transformation. The weighted remission rate was higher for surgical (92.8%) compared to non-surgical treatment (65.9%). The recurrence rate was lower for surgical (8.4%) compared to non-surgical treatment (19.2%). CONCLUSION: In this systematic review, the surgical treatment was more favorable than non-surgical for AC. Meanwhile, further studies are needed that should maximize methodological standardization and have greater rigor of the data collection process.